Sava Healthcare Stapban Ointment 15 gm

MUPIROCIN 2% OINTMENT

COMPOSITION:

Mupirocin            2.0% w/w

Water soluble base            q.s.

CHEMISTRY: 9 - 4 - [5S - (2S,3S - epoxy - 5S - hydroxy - 4S - methylhexyl) - 3R,4R - dihydroxytetrahydropyran - 2S - yl] - 3 - methylbut - 2(E) - enoyloxy - nonanoic acid.

CATEGORY: Antimicrobial

CLINICAL PHARMACOLOGY:

Mupirocin is a chemical entity produced by fermentation of the organism Pseudomonas fluorescens. Mupirocin inhibits bacterial protein synthesis by reversibly and specifically binding to bacterial isoleucyl transfer-RNA synthetase. Due to this mode of action, mupirocin shows no cross resistance with chloramphenicol, erythromycin, gentamicin, lincomycin, neomycin, novobiocin, penicillin, streptomycin, and tetracycline. Mupirocin is an antimicrobial agent that inhibits the growth of gram-positive and gram-negative bacteria.

Bacteria susceptible to the action of mupirocin in vitro include the aerobic isolates of Staphylococcus aureus (including methicillin-resistant strains and β-lactamase-producing strains), Staphylococcus intermedius, Staphylococcus epidermidis, other coagulase positive or negative Staphylococci, α-hemolytic Streptococci, β group A Streptococci (including S. pyogenes), other β Streptococci (including S. agalactiae), group D Streptococci (including S. faecalis and S. faecium), group Viridans Streptococci, Streptococcus pneumoniae, Corynebacterium hofmanii, Bacillus subtilis, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Proteus vulgaris, Enterobacter cloacae, Enterobacter aerogenes, Citrobacter freundii, Hemophilus influenzae (including β-lactamase-producing strains), Neisseria gonorrheae(including β-lactamase-producing strains), Neisseria meningitidis, Branhamella catarrhalis and Pasteurella multocida, and the anaerobic isolates of Peptostreptococcus anaerobius, Clostridium difficile, and Clostridium sporogenes.

INDICATIONS:

Mupirocin 2% Ointment is indicated for the topical treatment of canine bacterial infections of the skin, including superficial pyoderma, caused by susceptible strains of the following organisms: Staphylococcus aureus andStaphylococcus intermedius.

DOSAGE AND ADMINISTRATION:

Prior to treatment the lesion should be cleansed.

Mupirocin 2% Ointment should be applied to the affected area twice a day.

Apply a sufficient amount of ointment to completely cover the affected area.

The maximum duration of treatment should not exceed 30 days.

CONTRAINDICATIONS:

This drug is contraindicated in animals with a history of sensitivity reactions to any of its components.

WARNINGS AND PRECAUTIONS:

Mupirocin 2% ointment is not for ophthalmic use.

PREGNANCY AND LACTATION:

Safety of use in pregnant or breeding animals has not been determined.

ADVERSE DRUG REACTIONS:

No adverse reactions have been reported with this product. If a skin reaction such as irritation occur, treatment should be discontinued and appropriate therapy instituted.

OVERDOSAGE:

An overdose of Mupirocin 2% ointment is unlikely to occur. If an overdose is suspected, seek emergency veterinary medical treatment.

PRESENTATION: 15 g

STORAGE: Store in cool and dry place. Do not freeze. Keep out of reach of children.