Sava Healthcare Kiwof Plus XL Dewormer for Large AND Xtra Large Dogs

Sava Healthcare Kiwof Plus XL

KIWOF PLUS XL FOR DOGS

Each chewable tablet contains:

Praziquantel IP                             175 mg         

Pyrantel Pamoate IP                      504 mg                                           

Febantel                                        525 mg                                                                                   

Excipients                                       q.s.        

PHARMACOLOGY

KIWOF™ PLUS XL Tablets contain three active ingredients having different modes of action and spectra of activity. Praziquantel is active against cestodes (tapeworms). Praziquantel is absorbed, metabolized in the liver and excreted in the bile. Upon entering the digestive tract from the bile, cestocidal activity is exhibited. Following exposure to praziquantel, the tapeworm loses its ability to resist digestion by the mammalian host. Because of this, whole tapeworms, including the scolices, are very rarely passed after administration of praziquantel. In many instances only disintegrated and partially digested pieces of tapeworms will be seen in the stool. The majorities of tapeworms are digested and are not found in the feces.

Pyrantel pamoate is active against hookworms and ascarids. Pyrantel pamoate acts on the cholinergic receptors of the nematode resulting in spastic paralysis. Peristaltic action of the intestinal tract then eliminates the parasite.

Febantel is active against nematode parasites including whipworms. Febantel is rapidly absorbed and metabolized in the animal.

Available information suggests that the parasite’s energy metabolism is blocked, leading to energy exchange breakdown and inhibited glucose uptake.

INDICATIONS:

KIWOF™ PLUS XL Tablets are indicated for removal of Tapeworms (Dipylidium caninum, Taenia pisiformis, Echinococcus granulosus and removal and control of Echincoccus multilocularis). For removal of Hookworms (Ancylostoma caninum, Uncinaria stenocephala), Ascarids (Toxocara canis, Toxascaris leonina) and Whipworms (Trichuris vulpis) in dogs.

DOSAGE AND ADMINISTRATION:

For oral administration only.

The tablets can be given directly to the dog or disguised in food. No starvation is needed before or after treatment.

- For routine control adult dogs should be treated every 3 months. For routine treatment a single dose is recommended. In the event of heavy roundworm infestation a repeat dose should be given after 14 days.

KIWOF™ PLUS XL TABLETS DOSAGE GUIDE: FOR DOGS

17.5 kg body weight                                = ½ KIWOF™ PLUS XL Tablet

Over17.5 kg upto 35 kg body weight      = 1 KIWOF™ PLUS XL Tablet

Over 35 kg upto 52.5 kg body weight     = 1 ½ KIWOF™ PLUS XL Tablets

Over 52.5 kg upto 70 kg body weight     = 2 KIWOF™ PLUS XL Tablets

- For routine treatment a single dose is recommended.

PREGNANCY AND LACTATION:

- Consult a veterinary surgeon before treating pregnant animals for roundworms.

- The product may be used during lactation.

- Do not exceed recommended dose when treating pregnant bitches.

CONTRA-INDICATIONS, WARNINGS, ETC:

Do not use simultaneously with piperazine compounds.

USER SAFETY:

In the interests of good hygiene, persons administering the tablets directly to the dog, or by adding them to the dog’s food, should wash their hands afterwards.

ENVIRONMENTAL SAFETY:

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal product should be disposed of in accordance with local requirements.

PRECAUTIONS:

Strict hygienic precautions should be taken when handling dogs or feces suspected of harboring E. multilocularis. Infected dogs treated for the first time with KIWOF™ PLUS XL Tablets and dogs treated at intervals greater than 28 days may shed eggs in the feces after treatment. The animal should be held in the clinic during this interval and all feces should be incinerated or autoclaved. If these procedures are not possible, the eggs can be destroyed by soaking the feces in a sodium hypochlorite (bleach) solution of 3.75% or greater. All areas where the animal was maintained or in contact with should be thoroughly cleaned with sodium hypochlorite and allowed to dry completely before reuse.

KIWOF™ PLUS XL Tablets should be used alone and never combined with other de-worming medicine.

ADVERSE DRUG REACTIONS:

None reported. Vomiting was reported in some cases.

STORAGE: Store in cool and dry place. Protect from Light. Keep out of reach of children.

Veterinary

Not for human use

For treatment of animals only