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Sava Healthcare Metaflam Oral Suspension-15ml

Brand: SAVA HEALTHCARE
Product Code: PSI0001011
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Sava Healthcare Metaflam Oral Suspension-15ml

FEATURES

Meloxicam is a non-steroidal anti-inflammatory drug (NSAID) of the oxicam class which acts by inhibition of prostaglandin synthesis, thereby exerting anti-inflammatory, analgesic, anti-exudative and antipyretic effects. It reduces leukocyte infiltration into the inflamed tissue. To a minor extent it also inhibits collagen-induced thrombocyte aggregation. In vitro and in vivo studies have reported that meloxicam inhibits cyclooxygenase-2 (COX-2) to a greater extent than cyclooxygenase-1 (COX-1).

PHARMACOKINETICS:

Meloxicam has nearly 100% bioavailability when administered orally with food. The terminal elimination half-life after a single dose is estimated to be approximately 24 hrs (+/-30%) regardless of route of administration. There is no evidence of statistically significant gender differences in drug pharmacokinetics. Drug bioavailability, volume of distribution and total systemic clearance remain constant up to 5 times the recommended dose for use in dogs. However, there is some evidence of enhanced drug accumulation and terminal elimination half-life prolongation when dogs are dosed for 45 days or longer. Peak drug concentrations can be expected to occur within about 7.5 hrs after oral administration. Corresponding peak concentration is approximately 0.464 mcg/mL following a 0.09 mg/lb (0.2 mg/kg) oral dose. The drug is 97% bound to canine plasma proteins.

INDICATIONS:

Alleviation of inflammation and pain in both acute and chronic musculo-skeletal disorders in dogs.

DOSAGE AND ADMINISTRATION:

Metaflam oral suspension can be given using dropper bottle: Four drops for each kilogram of bodyweight on the first day and two drops for each kilogram of bodyweight daily as maintenance dose.

Dose regimen:

Day 0 (0.2 mg meloxicam/kg bodyweight on the first day).	Maintenance Dose (0.1 mg meloxicam/kg bodyweight).
0.25 ml – 1.9 kg	0.25 ml – 3.75 kg
0.3 ml– 2.25 kg	0.3 ml– 4.5 kg
0.5 ml – 3.75 kg	0.5 ml – 7.5 kg
0.6 ml – 4.5 kg	0.6 ml – 9.0 kg
1 ml – 7.5 kg	1 ml – 15 kg
1.5 ml – 11.25 kg	1.5 ml – 22.5 kg
2 ml – 15 kg	2 ml – 30 kg
2.5 ml – 18.75 kg	2.5 ml – 37.5 kg
3 ml – 22.5 kg	3 ml – 45 kg
3.5 ml – 26.25 kg	3.5 ml – 52.5 kg
4 ml – 30 kg	4 ml – 60 kg
4.5 ml – 33.75 kg	4.5 ml – 67.5 kg
5 ml - 37.5 kg	5 ml – 75 kg